Figure 2. Effect of berberine and evodiamine (BE) at high, medium, and low doses (BEH, BEM, BEL) or fenofibrate (FF) on lipid accumulation and pathological lesions of the liver of animals fed a high-fat diet (HFD). A, Changes in body weights, (B) epididymal fat weights, and (C) liver/body weight ratio. Serum levels of (D) triglyceride (TC), (E) total cholesterol (TG), (F) alanine aminotransferase (ALT), (G) aspartate aminotransferase (AST), (H) alkaline phosphatase (ALP), and (I) γ-glutamyl transferase (γ-GT). J, Representative macroscopic images of livers; K, Oil-Red-O staining; and L, hematoxylin and eosin (HE) staining images of the liver (magnification: 200×, scale bar: 100 µm). The black arrows represent circular vacuoles; the blue arrows represent inflammatory cell infiltration. Data are reported as means±SD. ***P<0.001 (one-way ANOVA).