Table 2.
Histological Quantitative Evaluation of Gastric Tissue Sections
| Experimental Groups N=6 | Mucosal Erosion (Mean%) * | Edema & Inflammatory Exudate (Mean%) * | Inflammatory Cells (Mean%) * | Necrotic Debris (Mean%) * | Hemorrhage (Mean%) * | Lesion Scoring (0 −100%) | Lesion Grading |
|---|---|---|---|---|---|---|---|
| (G1) NCG | 2.03% A# | 5.76%A | 7.12%A | 4.76%A | 8.01%A | 0–10% | No lesion |
| (G2) PCG | 94.23% E | 91.07%E | 93.28%E | 88.56%E | 84.67%D | 75–100% | Severe |
| (G3) PCG+LPZ 30mg/kg | 58.35%B | 71.21%D | 73.42%D | 56.81%B | 64.98%C | 50–75% | Moderate |
| (G4) PCG+AZI 1mg/kg | 81.56%D | 87.39%E | 84.21%D | 79.82%D | 75.14%D | 75–100% | Severe |
| (G5) PCG+AZI 5mg/kg | 76.19%D | 74.11%D | 79.85%D | 73.25%D | 74.89%D | 50–100% | Moderate-Severe |
| (G6) PCG+AZI 10mg/kg | 62.73%C | 73.61%D | 74.81%D | 64.19%C | 59.79%B | 50–75% | Moderate |
Notes: *All morphometric values of lesion scoring analysis were estimated in mean average, each value represents the mean percentage (%) of eight animals (n=8). #Statistical comparison among groups: Mean values with different capital letters (A,B,C,D,E) have significant differences at (P < 0.05). G1: Negative control group (NCG); G2: Positive control group (PCG); G3: Positive control group with Lansoprazole (LPZ) 30 mg/kg; G4: Positive control group with Azilsartan (AZI) 1 mg/kg; G5: Positive control group with Azilsartan (AZI) 5 mg/kg; G6: Positive control group with Azilsartan (AZI) 10 mg/kg.