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. 2022 May 17;80:104062. doi: 10.1016/j.ebiom.2022.104062

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 8 — Cross-reactive specific T-cell responses against SARS-CoV-1 and MERS of convalescent COVID-19 patients after in-vitro stimulation with the CD40.CoV2 vaccine. Frequency of total cytokines (IFN-γ ± IL-2 ± TNF) produced by specific CD4⁺ (blue) or CD8⁺ (green) T cells after in-vitro stimulation with the CD40.CoV2 vaccine (1 nM) on D0 and re-stimulation with OLPs representing the sequences of S1, vRBD, and vN2 from (a) SARS-CoV-1 and (b) S1 from MERS (1 µg/mL). Median values ± IQRs are shown. The [Wilcoxon U test] was used for comparisons (**P < 0.01, ***P < 0.001, ns: not significant).