Table 1.

Baseline (t = 0 at each study visit) reproductive hormones, bone turnover markers, bone, and renal biochemistry did not differ at commencement of placebo compared with kisspeptin visit

Analyte	Placebo	Kisspeptin	P-value
Reproductive hormones
Kisspeptin (pmol/L)	31.3 ± 3.2	36.5 ± 1.7	.16
LH (IU/L)	2.6 ± 0.2	2.6 ± 0.2	.82
FSH (IU/L)	2.3 ± 0.2	2.4 ± 0.2	.28
Testosterone (nmol/L)	20.7 ± 1.0	20.4 ± 1.0	.69
Bone turnover markers
Gla OC (ng/mL)	21.0 ± 1.6	19.0 ± 1.8	.24
Total OC (ng/mL)	30.8 ± 2.1	28.0 ± 2.3	.19
P1NP (ng/mL)	72.8 ± 8.4	71.1 ± 7.6	.64
CTx (ng/mL)	0.55 ± 0.05	0.55 ± 0.06	.99
Bone biochemistry
Adjusted calcium (mmol/L)	2.3 ± 0.01	2.3 ± 0.01	.13
Phosphate (mmol/L)	1.1 ± 0.03	1.1 ± 0.02	.76
PTH (pmol/L)	3.8 ± 0.2	3.3 ± 0.3	.08
Vitamin D (nmol/L)	50.6 ± 5.4	50.4 ± 5.0	.83
Total ALP (u/L)	56.4 ± 2.3	57.4 ± 2.2	.69
Albumin (g/L)	44.3 ± 0.5	44.2 ± 0.5	>.99
Total Protein (g/L)	71.0 ± 1.1	70.1 ± 1.0	.34
Renal biochemistry
Sodium (mmol/L)	140.4 ± 0.4	140.4 ± 0.5	.84
Potassium (mmol/L)	4.5 ± 0.1	4.4 ± 0.1	.55
Creatinine (μmol/L)	98.3 ± 2.7	94.5 ± 3.1	.16

Data distributed normally and presented as mean ± SEM, 2-way paired t-test, n = 26 healthy men.