Table 3.
Associations between risk factors and bone turnover markers among Epidemiology of Diabetes Interventions and Complications participants, multivariable model
| Risk factors | PINP, pg/mL | Bone ALP, U/L | sCTX (pg/mL) | TRACP5b (U/L) | ||||
|---|---|---|---|---|---|---|---|---|
| Estimate (95% C.I.) | P-value | Estimate (95% C.I.) | P-value | Estimate (95% C.I.) | P-value | Estimate (95% C.I.) | P-value | |
| Current HbA1c (per 1%) | -3.4 (-6.1, -0.7) | 0.015 | 0.2 (-0.5, 0.8) | 0.669 | -10.1 (-28.3, 8.1) | 0.274 | -0.07 (-0.21, 0.07) | 0.337 |
| eGFR (per -20 mL/min/1.73 m2) | 6.9 (3.8, 10.0) | <0.0001 | 1.0 (0.2, 1.9) | 0.011 | 53.6 (32.6, 74.6) | <0.0001 | 0.3 (0.1, 0.4) | 0.002 |
| AGE (SIF) (per 5 units) | 2.5 (-1.1, 6.1) | 0.176 | 0.7 (-0.3, 1.6) | 0.170 | 13.3 (-11.1, 37.7) | 0.284 | 0.17 (-0.02, 0.35) | 0.086 |
Models were adjusted for age, sex, and menopause. Bolded values are P < 0.05.
Abbreviations: AGE, advanced glycation end products; bone ALP, bone-specific alkaline phosphatase; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; PINP, procollagen 1 intact N-terminal propeptide; sCTX, serum C-telopeptide; SIF, skin intrinsic fluorescence; TRACP5b, tartrate-resistant acid phosphatase 5b.