Table 1.
Clinical and epidemiological characteristics
| Basic demographics | Hypothyroidism | Graves disease |
|---|---|---|
| Prevalence of total AAD cohort, No. (%) | 380/912 (42%) | 78/912 (8.6%) |
| No. of female patients (%) | 271 (71%) | 60 (77%) |
| Age at onset of AAD, median (range) | 36.0 (3-85) | 33.5 (14-64) |
| Age at onset of autoimmune thyroid disease, median (range) | 38.0 (2-87) | 33.0 (9-89) |
| Y between AAD and thyroid disease, median (range) | 0 (–52 to 59) | 1.0 (–55 to 37) |
| Autoantibodies, No. (%) | ||
| 21-Hydroxylase antibodies | 357/377 (95%)a | 75/78 (96%) |
| Thyroid peroxidase antibodies | 256/377 (68%)b | 43/78 (55%) |
| TSH-receptor antibodies | 50/61 (82%)c | |
| Associated autoimmune diseases, No. (%) | ||
| Type 1 diabetes mellitus | 68/380 (18%) | 12/78 (15%) |
| B12 deficiency | 36/380 (9.5%) | 12/78 (15%) |
| Gonadal insufficiency | 26/380 (6.8%) | 4/78 (5.1%) |
| Vitiligo | 51/380 (13%) | 13/78 (17%) |
| Celiac disease | 18/380 (4.7%) | 6/78 (7.7%) |
| Alopecia | 21/380 (5.5%) | 4/78 (5.1%) |
| Coexisting diseased | 16/380 (4.2%) | 16/78 (21%) |
| Total: ≥ 1 associated disease | 187/380 (49%) | 44/78 (56%) |
Abbreviations: AAD, autoimmune Addison disease; TSH, thyrotropin.
a Data missing for 3 patients.
b Data missing for 3 patients.
c Data missing for 17 patients.
d Patients that were diagnosed both with autoimmune hypothyroidism and hyperthyroidism.