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Knockdown of p300 inhibits cell proliferation, clone formation, and the acetylation of H3. (a, b) The protein and mRNA expression of p300 in GH3 cells after transfection with p300-siRNAs, the negative control, and the mock control. (c) The protein expression of H3K18ac and H3K27ac in p300-knockdown GH3 cells. (d) Cell proliferation of p300-knockdown GH3 cells. (e) Clone formation by p300-knockdown GH3 cells. *P < 0.05, **P < 0.01, ***P < 0.001. The bar represents ± SD.
