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. 2022 Mar 5;107(6):e2291–e2300. doi: 10.1210/clinem/dgac128

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Exploration of the potential mechanism affected by A-485. (a) Heat maps of differentially expressed genes at different concentrations of A-485. (b) Venn diagrams showing the overlapping genes between each group. (c) The fold changes in hub genes based on the RNA sequencing. (d) The mRNA expression of hub genes was verified by qRT-PCR. (e) KEGG analysis indicated the specific signaling pathways affected by A-485. (f) The protein expressions of key molecules affected by A-485 were detected by Western blotting. The bar represents ± SD.