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. 2022 Feb 3;107(6):e2590–e2599. doi: 10.1210/clinem/dgac043

Figure 2.

Figure 2.

Differences in CNS activation after 10 days of treatment. A, Axial slice showing average differences between dapagliflozin and placebo in left putamen (PFWE < 0.01), T = 3.2) (yellow dot) in response to the viewing of high-calorie vs nonfood pictures. B, Axial slice showing average differences between exenatide and placebo in left putamen (PFWE < 0.05, T = 3.4) (yellow dot) in response to the viewing of high-calorie food pictures vs nonfood pictures. The left side of the axial slices is the left side of the brain. The color scale reflects the T value of the functional activity. Results are presented at the threshold of P < 0.05, familywise error (FWE) corrected for cluster extent. In the graphs, BOLD signal intensity (effect size) is plotted (arbitrary units), mean and SEM. The x,y,z, describes the coordinates of the peak voxel of the observed difference in MNI (Montreal Neurological Institute) space. Abbreviation: BOLD, blood oxygen level–dependent.