Table 10.
Glycemic variability metrics and glycated hemoglobin A1c
| CGM marker | No. of papers showing associations of glucose metrics with diabetes complications after adjusting for HbA1c | No. of papers in which statistical significance was lost after adjusting for HbA1c |
|---|---|---|
| SD | 7 | 3 |
| MAGE | 7 | 1 |
| TIR (and time-out-of-range) | 5 | 1 |
| CV | 3 | 0 |
| TBR (and AUC TBR) | 2 | 0 |
| LBGI | 2 | 0 |
| CONGA-2 | 0 | 2 |
| HBGI | 1 | 1 |
| TAR | 1 | 0 |
Abbreviations: AUC, area under the curve; CGM, continuous glucose monitoring; CONGA, continuous overall net glycemic action; CV, coefficient of variation for glucose; HbA1c, glycated hemoglobin A1c; HBGI, high blood glucose index; LGBI, low blood glucose index; MAGE, mean amplitude of glycemic excursions; SD, SD of blood glucose levels; TAR, time above range; TBR, time below range; TIR, time in range.