Figure 4.

Association of cFGF23, α-Klotho, and mineral parameters with bone density measured by calcaneal ultrasound. Dark lines represent associations with bone density (measured as calcaneal QUS stiffness index) as betas compared to the point of lowest risk, highest risk, or the median for each parameter. They are adjusted for a bone density score (including age [treated flexibly with restricted cubic splines], sex, ethnicity, body mass index [treated flexibly with restricted cubic splines], prior fracture at any anatomical site, active smoking, diabetes, prevalent cardiovascular disease, alcohol consumption [treated flexibly with restricted cubic splines], secondary osteoporosis), and chronic kidney status. Shaded areas represent the 95% CI at each level. Associations and confidence intervals were generated from 10 multiply imputed datasets using Rubin’s rules. Lines below each plot represent the distribution of parameters for each patient. Abbreviations: PTH, parathyroid hormone; QUS, quantitative ultrasound.