Table 2.
Association of cFGF23, α-Klotho, and mineral parameters with fracture incidence at any site
| Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|
| Overall (n = 312) | Non-CKD (n = 159) | CKD (n = 153) | Interaction P | ||
| cFGF23 (per doubling) | 1.81 (1.71, 1.93)a | 1.99 (1.84, 2.14)a | 2.03 (1.87, 2.19)a | 1.73 (1.35, 2.21)a | 0.226 |
| α-Klotho (per doubling) | 0.68 (0.51, 0.89)a | 1.04 (0.91, 1.20) | 1.11 (0.96, 1.29) | 0.60 (0.33, 1.09) | 0.050 |
| PTH (per doubling) | 0.80 (0.71, 0.89)a | 1.10 (0.99, 1.23) | 1.00 (0.91, 1.11) | 1.69 (1.12, 2.55)a | 0.015 |
| Phosphate (per 0.1 mmol/L) | 1.04 (0.99, 1.09) | 0.94 (0.90, 0.98)a | 0.92 (0.88, 0.96)a | 1.12 (0.94, 1.32) | 0.031 |
| Calcium (per 0.1 mmol/L) | 1.07 (0.99, 1.15) | 0.95 (0.88, 1.03) | 0.96 (0.88, 1.04) | 0.94 (0.55, 1.60) | 0.938 |
Associations are presented as hazard ratios (95% CI). Hazard ratios and confidence intervals were generated in 10 multiply imputed datasets and combined using Rubin’s rules. The adjusted model includes a risk score for fractures built in the overall cohort (including age [treated flexibly with restricted cubic splines], sex, ethnicity, body mass index [treated flexibly with restricted cubic splines], prior fracture at any anatomical site, active smoking, diabetes, prevalent cardiovascular disease, alcohol consumption [treated flexibly with restricted cubic splines], secondary osteoporosis) and chronic kidney disease status.
Abbreviations: CKD, chronic kidney disease; PTH, parathyroid hormone.
aIndicates P value for association < 0.05.