Table 3.
Association of cFGF23, α-Klotho, and mineral parameters with bone mineral density measured by calcaneal ultrasound
| Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|
| Overall (n = 312) | Non-CKD (n = 159) | CKD (n = 153) | Interaction P | ||
| cFGF23 | 1.46 (−1.29, 4.21) | −0.71 (−2.57, 1.15) | −0.93 (−3.19, 1.34) | 1.01 (−3.23, 5.25) | 0.452 |
| α-Klotho | −3.91 (−9.26, 1.43) | −7.05 (−10.5, −3.64)a | −7.56 (−11.20, −3.91)a | −2.68 (−4.02, 9.39) | 0.012 |
| PTH | −1.69 (−3.70, 0.32) | −4.69 (−5.73, −3.64)a | −4.72 (−5.84, −3.61)a | −2.39 (−5.80, 1.01) | 0.204 |
| Phosphate | −8.87 (−11.72, −6.00)a | −7.60 (−11.67, −3.52)a | −7.60 (−12.03, −3.18)a | −8.18 (−20.16, 3.80) | 0.931 |
| Calcium | −30.28 (−47.20, −13.36)a | −13.49 (−33.26, 6.28) | −13.51 (−34.05, 7.03) | −5.63 (−54.04, 42.77) | 0.749 |
Bone density was measured using calcaneal quantitative ultrasound and stiffness index was used for these analyses. Associations are presented as beta (95% CI) per percent increase. Associations and confidence intervals were generated in 10 multiply imputed datasets and combined using Rubin’s rules. The adjusted model includes an adjustment score for stiffness index built in the overall cohort (including age [treated flexibly with restricted cubic splines], sex, ethnicity, body mass index [treated flexibly with restricted cubic splines], prior fracture at any anatomical site, active smoking, diabetes, prevalent cardiovascular disease, alcohol consumption [treated flexibly with restricted cubic splines], secondary osteoporosis) and chronic kidney disease status.
Abbreviations: CKD, chronic kidney disease; PTH, parathyroid hormone.
aIndicates P value for association < 0.05.