Table 7.
Cumulative incidence function analysis of central fractures for each clinical risk factor
| Fracture events: 277 central fractures/Competing events: 124 deaths | ||||
|---|---|---|---|---|
| Central fractures CRF | Event, n (%) | 5-year CIF, % | P-value | n total |
| Age | <0.0001 | 3560 | ||
| ≤67 years | 56 (20.2) | 4.5 | ||
| 68-75 years | 98 (35.4) | 7.6 | ||
| ≥76 years | 123 (44.4) | 13.4 | ||
| Low BMI | 0.01 | 3560 | ||
| Yes | 39 (14.1) | 11.8 | ||
| No | 238 (85.9) | 7.5 | ||
| Obesity | 0.02 | 3560 | ||
| Yes | 39 (14.1) | 5.9 | ||
| No | 238 (85.9) | 8.3 | ||
| History of fracture | <0.0001 | 3533 | ||
| Yes | 122 (44.) | 12.6 | ||
| No | 155 (56) | 6.1 | ||
| History of falls | 0.01 | 3531 | ||
| Yes | 72 (26.3) | 10.5 | ||
| No | 202 (73.7) | 7.2 | ||
| Corticosteroid use | 0.02 | 3537 | ||
| Yes | 31 (11.2) | 11.8 | ||
| No | 246 (88.8) | 7.6 | ||
| Comorbidities | <0.0001 | 3560 | ||
| Yes | 47 (17) | 11.4 | ||
| No | 230 (83) | 7.4 | ||
| Sleep disturbances | 0.05 | 3500 | ||
| Yes | 154 (56.4) | 8.5 | ||
| No | 119 (43.6) | 7.2 | ||
| Rheumatoid arthritis | 0.001 | 3560 | ||
| Yes | 9 (3.3) | 23.7 | ||
| No | 268 (96.8) | 7.7 | ||
| Education level | 0.01 | 3537 | ||
| <9 years | 122 (44) | 9.7 | ||
| ≥9 years | 155 (56) | 6.9 | ||
| Early nonsubstituted menopause | 0.02 | 3549 | ||
| Yes | 18 (6.6) | 9.6 | ||
| No | 258 (93.5) | 7.8 | ||
| BMD status | <0.0001 | 3498 | ||
| Osteoporosis | 82 (30.8) | 17.6 | ||
| Osteopenia | 142 (53.4) | 7.6 | ||
| Normal | 42 (15.8) | 3.8 | ||
| T-score hip | <0.001 | 3457 | ||
| ≤−2.5 | 27 (10.3) | 26.6 | ||
| >−2.5 | 236 (89.7) | 7.1 | ||
| T-score femoral neck | <0.0001 | 3457 | ||
| ≤−2.5 | 43 (16.4) | 20.3 | ||
| >−2.5 | 220 (83.7) | 6.9 | ||
| T-score spine | <0.0001 | 3452 | ||
| ≤−2.5 | 52 (19.8) | 16.6 | ||
| >−2.5 | 211 (80.2) | 6.8 |
Abbreviations: BMD, bone mineral density; CIF, cumulative incidence function; CRF, clinical risk factor.