Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 10;29(5):484–493. doi: 10.1038/s41417-022-00428-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — A Non-coding variants in the genomic region chr11:69450872-69469242 (hg19) covering the CCND1 locus including 5 kb upstream of the TSS were collected for all MCL and non-MCL samples. Red bars indicate the relative frequency of non-coding variants in the MCL cohort. Black bars refer to the relative frequency of non-coding variants in non-MCL samples. A screenshot from the UCSC genome browser of the CCND1 locus shows the density of H3K27 acetylation marks, the density of DNase 1 hypersensitivity sites, and transcription factor-binding regions, as well as the level of sequence conservation. The bars at the bottom of the panel indicate the distribution of individual variants in the first intron. The color of the bars indicates the number of samples a particular variant was observed in. B Plot of the percentage of samples with five or more non-coding variants in the CCND1 transcription regulatory region (chr11: 69450872-69458025, hg19) for indicated cohorts. Abbreviations for cohort names are described in Table 1. C Plot of the fraction of samples by the minimum number of non-coding variants in the CCND1 transcription regulatory region for Multiple Myeloma (MM) and MCL samples. Only samples carrying a t(11;14)(q13;q32) translocation and mutated IGHV status were included.