Table 2.
Mutational signatures were compared to known signatures compiled by COSMIC [32] using cosine similarity plots.
| SBS | MCL | non-MCL | Description |
|---|---|---|---|
| sbs1 | x | Spontaneous deamination of 5-methylcytosine (clock-like signature) | |
| sbs3 | x | x | Defective homologous recombination DNA damage repair |
| sbs5 | x | x | unknown (clock-like signature) |
| sbs6 | x | x | Defective DNA mismatch repair |
| sbs9 | x | x | Polymerase eta somatic hypermutation activity |
| sbs15 | x | Defective DNA mismatch repair | |
| sbs23 | x | Unknown | |
| sbs31 | x | Platinum chemotherapy treatment | |
| sbs39 | x | x | Unknown |
| sbs40 | x | x | Unknown |
| sbs42 | x | x | Haloalkane exposure |
| sbs44 | x | x | Defective DNA mismatch repair |
| sbs84 | x | x | Activity of activation-induced cytidine deaminase (AID) |
| sbs87 | x | Thiopurine chemotherapy treatment |
Signatures with cosine similarity values above the background are shown and marked with “x” depending on the cohort where they were detected.