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. 2021 Apr 8;29(5):505–518. doi: 10.1038/s41417-021-00326-4

Fig. 3. Glutamine is crucial for energy production and the redox balance in KRAS mutant pancreatic epithelial cells.

Fig. 3

a Oxygen consumption rate. Results are the means of five biological replicates; error bars represent the SD. *p < 0.05; **p < 0.01. b Intracellular ATP levels. Results are the means of three biological replicates; error bars represent the SD. *p < 0.05. c Intracellular ATP levels under normal and Gln-deficient conditions with the calculated ratios (ATP levels in Gln−/levels in Gln+). Results are the means of three biological replicates; error bars represent the SD. *p < 0.05. d Intracellular ROS levels. Results are the means of three biological replicates; error bars represent the SD. NS, not significant. e GSH/GSSG ratio assessed from the metabolome data and relative ratios taking the value of control HPNE cells as 1. Results are the means of three biological replicates; error bars represent the SD. NS, not significant. f Intracellular ROS levels under normal and Gln-deficient conditions with the calculated ratios (ROS levels in Gln−/levels in Gln+). Results are the means of three biological replicates; error bars represent the SD. *p < 0.05.