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. 2021 Apr 14;29(5):533–542. doi: 10.1038/s41417-021-00324-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A–C Long Evan rats received IV f-ON (10.5 mg/kg; IV) either alone (A) or 1 day after 5 Gy whole-brain irradiation (B), (C). Brains were harvested 1 day after f-ON administration. Sections were counterstained with Hoechst nuclear stain and fluorescein localization was analyzed. C High magnification field showing punctate cellular uptake of f-ON. D–F Athymic nude rats with D283 tumor received f-ON alone (D) or 1 day after 2 Gy brain irradiation observed; representative micrographs under low magnification (E) or high magnification (F). Brains were harvested 1 day after f-ON administration and sections were stained for human mitochnondrial antigen (HMT) and ionized calcium-binding adapter molecule 1 (IBA1) as a marker of human tumor cells and microglia. Scale bar = 100 μm (A, B), 20 µm (C), or 10 µm (D, E, F), respectively. (T tumor and *representative f-ON positive cells).