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. 2021 Apr 14;29(5):533–542. doi: 10.1038/s41417-021-00324-6

Fig. 4. AMON increased the efficacy of chemo-radiation therapy (CRT) in the D283 medulloblastoma orthotropic brain tumor model.

Fig. 4

Athymic nude rats were inoculated with MGMT expressing D283 medulloblastoma cerebellar orthotropic xenografts (n = 14). Tumor-bearing rats received a single dose of 2 Gy radiation with four daily doses of oral temozolomide (20 mg/kg × 4 days). AMONs (10.5 mg/kg; IV) were administered 1 day after radiation to half (n = 7) of animals and all tumors were harvested 7 days after the start of CRT. A Scheme of experimental design and treatment regime. B Representative after-treatment brain tumor histology from each treatment group. C Total tumor volumes and (D) disseminated tumor volumes are shown for individual animals. Data were presented as mean ± SEM. Statistical significance indicated by *P < 0.05. **P < 0.01.