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. 2022 Apr 21;29(5):420–429. doi: 10.1038/s41594-022-00755-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6. — (a) Conserved structural motifs common to all CCT subunits (here represented by CCT1) including apical lid helices, proximal loop, release loop of substrate (RLS), P-loop, nucleotide-sensing loop (NSL), and stem loop. Insets: Motifs are coloured orange and density map is shown grey. (b,c) Snapshots of ligand density in the nucleotide binding site for each CCT subunit of closed-TRiC (b) and open-TRiC (c). Dashed lines represent hydrogen bonding. ADP molecules are shown in yellow with Mg²⁺ in green and water molecules are represented in red spheres.