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. 2022 Apr 21;29(5):420–429. doi: 10.1038/s41594-022-00755-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — (a) Flattened surface representation showing conformational differences between closed-TRiC and open-TRiC in the equatorial (E), intermediate (I) and apical (A) domains. (b) Views of the network of N-terminal extensions between subunits across the ring interface in closed-TRiC state (top). Note that these interactions were not observed in open-TRiC state (bottom) due to disorder of the N-terminal extensions. (c,d) Flat rendering of the CCT2-CCT2’ inter-ring stacking in closed-TRiC (c) and open-TRiC (d). Compared to closed-TRiC, rearranged helix α15 pushes loop α4-α5 from the trans subunit away from the interface. Inter-ring contacts are now mediated between the entire helical face of α15, and loop α13-α14 from the trans subunit.