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. 2022 Apr 21;29(5):420–429. doi: 10.1038/s41594-022-00755-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, Filtered 4.0-Å resolution reconstruction map of open TRiC in side (left) and top (right) views. b, Cartoon representation showing apical domains built into map, as well as intermediate and apical domains modeled by flexible fitting; same views as a. c, Side slice of open TRiC with substrate density in cyan. d, Slice of substrate density at low isosurface threshold, in the septum of open TRiC. e, Proposed mechanism of TRiC-mediated substrate folding based on this work. TRiC structures shown are from this study (steps 2, 4, 5, 5') or from PDB 5GW4 (step 1). PFD, prefoldin.