Table 1. Summary of plaque formation, cognitive impairment, and impaired AHN in commonly used AD mouse models.

Mouse model	Age of plaque formation (Hippocampus, month)	Age of cognitive impairment (month)	AHN change	Primary paper
N/A: Not available.
J20	6 (Hong et al., 2016)	4 (Cheng et al., 2007; Wright et al., 2013)	3 months ↑ (López-Toledano & Shelanski, 2007) No change (Sun et al., 2009)	Mucke et al., 2000
			5 months ↓ (López-Toledano & Shelanski, 2007)
			12 months ↑ (Jin et al., 2004a)
5xFAD	6 (Oakley et al., 2006)	4–5 (Devi & Ohno, 2010; Oakley et al., 2006)	2–4 months ↓ (Moon et al., 2014; Zaletel et al., 2018)	Oakley et al., 2006
APPswe/ PS1ΔE9	6 (Jankowsky et al., 2004)	12 (Lalonde et al., 2005; Volianskis et al., 2010)	2 months ↓ (Demars et al., 2010)	Jankowsky et al., 2004
			6 months ↓ (Verret et al., 2007)
3xTg	6 (Oddo et al., 2003)	4 (Billings et al., 2005; Stover et al., 2015)	2–4 months ↓ (Hamilton et al., 2015; Rodríguez et al., 2008)	Oddo et al., 2003
			6 months ↓ (Valero et al., 2014)
			11, 18 months ↓ (Hamilton et al., 2010)
Tg2576	6 (Westerman et al., 2002)	10 (Arendash & King, 2002)	3 months ↑ proliferation / ↓ Survival (Krezymon et al., 2013)	Hsiao et al., 1996
APP NL-G-F Knock-in	4 (Saito et al., 2014)	6 (Saito et al., 2014)	N/A	Saito et al., 2014
AppSAA Knock-in	4 (Xia et al., 2021)	N/A	N/A	Xia et al., 2021