Figure 5.

Administration of Lor. or Lor./remdesivir blocks MC accumulation

A: Mock infection. B: BALB/c mice were infected intranasally with SARS-CoV-2 501Y.V2 strain (7.1×10⁴ CCID50). C: Remdesivir (25 mg/kg) was administered (i.p.) at time of infection and used once daily until euthanasia. D, E: In some mice, Lor. (10 mg/kg) was administered (i.p.) 1 day before infection, then continued each day over the course of infection. Lungs were collected at 3 dpi. Toluidine blue staining of lung sections was used to observe MCs and their degranulation. Scale bar: 100 μm.