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. 2022 May 17;12:8126. doi: 10.1038/s41598-022-11986-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative images of adipose tissue-derived multi-lineage progenitor cell (ADMPC) transplantation. (a) Pre-operative intra-oral findings. This case was a 51-year-old female. The test tooth was an upper left second molar with a 6-mm periodontal pocket in the distal area. (b, c) Intra-oral findings during periodontal surgery. The flap operation was performed in accordance with the modified Widman procedure. After reversing the gingival flap, a circumferential intra-bony defect filled with granulation tissue was revealed and the granulation tissue was removed. After washing the intra-bony defect with normal saline, ADMPCs mixed with fibrin gel were transplanted into the intra-bony defect. (d) Postoperative intra-oral findings. Four weeks after ADMPC transplantation, no abnormal findings were found at the surgical site.