Table 1.

All breast cancer studies including TSR assessments of tumor resection material with interobserver agreement values and relevance

Study	Number of patients (N)	Interobserver score (κ value)	Relevance of the TSR
De Kruijf EM et al. [4]	574	0.85	Prognostic (primary operable BC)
Moorman AM et al. [7]	124	0.74	Prognostic (TNBC)
Dekker TJ et al. [8]	403	0.804	Prognostic (node-negative BC)
Downey CL et al. [48]	63 (subset)	0.70	Prognostic (ER-positive BC)
Roeke T et al. [9]	737	0.68	Prognostic (primary operable BC)
Vangangelt KMH et al. [10]	344	0.85	Prognostic (primary operable BC combined with immune status)
Vangangelt KMH et al. [11]	191	0.85	Prognostic (BC with positive axillary nodes)
Vangangelt KMH et al. [49]	619	0.77	Amount of BC stroma increases with age
Vangangelt KMH et al. [12]	1794	0.87	Prognostic (primary operable BC)
Xu Q et al. [13]	240	0.77	Prognostic (invasive BC)
Zakhartseva LM et al. [50]	232	0.84	Prognostic (primary operable BC)

BC breast cancer, TNBC triple-negative breast cancer, ER estrogen receptor