Fig. 5.

METTL3-mediated m⁶A RNA methylation regulates Hippo and Wnt pathways. a Consensus motif of m⁶A sites in Mettl3^fl/fl mice. b Enrichment of m6ARIP-seq peaks in Mettl3^fl/fl mice and K14-cre; Mettl3^fl/fl mice at P4. c KEGG pathway enrichment for highly modified mRNAs. d The read density from m6ARIP-seq experiments shows the m⁶A peaks in Mettl3^fl/fl mice and decreased peaks in K14-cre; Mettl3^fl/fl mice. e Decreased expression of LATS1 in conditional Mettl3 knock-out mice at P4. Scale bar: 20 μmol·L⁻¹. f Western blot analysis of FZD7 in Mettl3^fl/fl mice and K14-cre; Mettl3^fl/fl mice. g, h Immunofluorescence assays are used to detect the expression and location of YAP and TAZ. Scale bar: 20 μmol·L⁻¹. i, j Immunofluorescence assays are used to detect the expression and localization of β-catenin and LEF1. Scale bar: 20 μmol·L⁻¹