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. 2022 May 17;12:8159. doi: 10.1038/s41598-022-12358-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Neutrophil elastase inhibitor decreases the gene transcription of proinflammatory cytokines in the murine gingiva. Messenger RNA transcription levels of Il6, Il1b, and Cxcl1 in the palatal gingiva of mice from the indicated groups were determined by real-time PCR. Relative mRNA levels were normalized to those of Gapdh. Data are presented as the mean ± SD (n = 5 per group). The group means were compared using one-way analysis of variance with Tukey’s multiple comparison test. NE neutrophil elastase, SD standard deviation.