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. 2022 May 17;12:8211. doi: 10.1038/s41598-022-11926-x

Table 3.

AUC data from single biochemical marker/systemic inflammation index ROC curves.

Biomarker/Index AUC 95% CI P
HC vs. SS LDH 0.7431 0.6161–0.8701 0.0009
ACE 0.8190 0.7248–0.9131  < 0.0001
Fibrinogen 0.7780 0.6358–0.9201 0.0014
NLR 0.7382 0.6243–0.8521 0.0011
PLR 0.7532 0.6379–0.8685 0.0005
LMR 0.767 0.6449–0.8891 0.0003
SII 0.7338 0.6138–0.8537 0.0014
SIRI 0.7377 0.6108–0.8646 0.0014
AISI 0.7143 0.5818–0.8468 0.0039
HC vs. PMF LDH 0.8374 0.7291–0.9457  < 0.0001
ACE 0.9142 0.8446–0.9838  < 0.0001
Fibrinogen 0.7870 0.6466–0.9275 0.0018
NLR 0.8281 0.7234–0.9328  < 0.0001
PLR 0.8100 0.6916–0.9285  < 0.0001
LMR 0.8535 0.7531–0.9539  < 0.0001
SII 0.8054 0.6922–0.9185  < 0.0001
SIRI 0.8138 0.7060–0.9215  < 0.0001
AISI 0.8059 0.6951–0.9167 0.0001
SS vs. PMF LDH 0.6811 0.5689–0.07933 0.0028
ACE 0.5747 0.4570–0.6924 0.2258
Fibrinogen 0.6179 0.4713–0.7645 0.1072
NLR 0.5595 0.4438–0.6753 0.3254
PLR 0.5385 0.4224–0.6546 0.5251
LMR 0.6277 0.5133–0.7422 0.0348
SII 0.5733 0.4574–0.6891 0.2261
SIRI 0.6264 0.5102–0.7426 0.0368
AISI 0.6227 0.5075–0.7379 0.0426

AUC, area under the ROC curve; 95% CI, 95% confidence interval; LDH lactate dehydrogenase; ACE angiotensin convertase enzyme; NLR (neutrophil/lymphocyte ratio), PLR (platelet/lymphocyte ratio), LMR (lymphocyte/monocyte ratio), SII (neutrophil x platelet/lymphocyte ratio), SIRI (neutrophil x monocyte/lymphocyte ratio) and AISI (neutrophil x monocyte x platelet/lymphocyte ratio). 95% CI, 95% confidence interval; P, p value.