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. 2022 May 17;12:8224. doi: 10.1038/s41598-022-11020-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative TAF and drug metabolite spatial distribution profiles in mouse dermal tissue sections adjacent to low-releasing (0.23 mg d^-1) TAF implants, with the implants remaining in situ within the encasing tissue block excised at necropsy, on study Day 14. (A) Light microscopy image of the tissue section. (B) H&E Serial section stain of matching tissue specimen. (C–H) Overlay of mass spectrometry images, generated at a spatial resolution of 100 µm, and light microscopy images of the tissue specimens. (C) TAF; (D) Metabolite X; (E) Metabolite Y; (F) TFV; (G) TFV-MP; and (H) TFV-DP. Color key in the legend indicates relative ion abundance, with red representing the highest signal intensity (100%) and blue representing the lowest signal (0%) for the corresponding measured ion; all images were scaled individually. Scale bar, 2 mm.