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. 2022 May 17;12:8224. doi: 10.1038/s41598-022-11020-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Dermal tissues collected adjacent to the TAF implant from the low-releasing group, aldehyde-fixed, paraffin-embedded, sectioned, and H&E-stained. The specimens span the 28-day period where the implants were in place and representative samples from all animals (N = 3 per timepoint) are included; D3, D7, D14, D21, and D28 indicate tissue specimens collected with the TAF implant in place at study days 3, 7, 14, 21, and 28, respectively. Scale bar, 1 mm. (B) Dermal tissues collected adjacent to the TAF implant from the high-releasing group, aldehyde-fixed, paraffin-embedded, sectioned, and H&E-stained. The specimens span the 28-day period where the implants were in place and representative samples from all animals (N = 3 per timepoint) are included; D3, D7, D14, D21, and D28 indicate tissue specimens collected with the TAF implant in place at study days 3, 7, 14, 21, and 28, respectively. Scale bar, 1 mm.