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. 2022 May 17;12:8224. doi: 10.1038/s41598-022-11020-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue homogenate drug concentration–time profiles following intravenous TAF dosing in C57BL/6 J mice. Blue, TFV; green, TFV-DP. The sampled anatomic compartments are: (A) and (E), vaginal (median tissue mass, 192 mg/sample); (B) and (F) rectal (median tissue mass, 71 mg/sample); (C) and (G) spleen (median tissue mass, 106 mg/sample); and (D) and (H) thymus (median tissue mass, 68 mg/sample). The assay LLOQs are: TFV (based on 0.05 ng/sample), vaginal 0.9 fmol mg^-1; rectal, 2.4 fmol mg^-1; spleen, 1.6 fmol mg^-1; thymus, 2.6 fmol mg^-1; TFV-DP (based on 5 fmol/sample), vaginal 0.03 fmol mg^-1; rectal, 0.07 fmol mg^-1; spleen, 0.05 fmol mg^-1; thymus, 0.07 fmol mg^-1.