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. 2022 May 17;12:8224. doi: 10.1038/s41598-022-11020-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Subdermal placement of TAF implants in C57BL/6 J mice maintains sustained drug concentrations. Data are presented as means ± SD (N = 3 per timepoint); circles, low-releasing implants (0.28 mg d^-1 in vivo); squares, high-releasing implants (0.58 mg d^-1 in vivo). Pharmacokinetic profiles of (A) plasma TFV; (B) PBMC TFV-DP; (C) dermal tissue (collected adjacent to the implant) TFV; and (D) dermal tissue TFV-DP. The assay LLOQs are: plasma TFV, 3.5 nM (1 ng mL^-1); PBMC TFV-DP, 13 nM (based on 5 fmol/sample, and a median of 1.9 × 10⁶ PBMCs per sample); tissue TFV 21 fmol mg^-1 (based on 0.05 ng/sample, and a median of 8.4 mg per sample); tissue TFV-DP 0.6 fmol mg^-1 (based on 5 fmol/sample, and a median of 8.4 mg per sample).