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. 2022 May 17;12:8224. doi: 10.1038/s41598-022-11020-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pharmacokinetic model for plasma TFV and intracellular TFV-DP in mice, based on the model reported by Duwal et al.⁴⁴. IV dosing occurs in the C1 compartment, SQ and implant dosing occur in the D compartment (dosing reservoir). The release rate into the D compartment is assumed instantaneous following SQ dosing, but is governed by the actual implant TAF release rate in the case of implant administration. The fraction of TAF metabolized to TFV is assumed to be 100%. V, volume of distribution of the central compartment; CL, total body clearance; V_p, volume of distribution of the second compartment; CL_p, clearance from the second compartment; t_1/2, elimination half-life; F, bioavailability/exposure scaling; K_a, absorption rate parameter; V_cell, PBMC physiological volume; K_out, elimination rate parameter; V_m, maximum rate achieved by the system using Michaelis–Menten kinetics; K_m, Michaelis constant.