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Simulated systemic drug concentrations in C57BL/6 J mice at 6 h following oral TAF dosing over a range of oral bioavailabilities (F).
| TAF dose µmol |
F | Plasma [TFV] nM (ng mL-1) |
PBMC [TFV-DP] nM (fmol/106 cells) |
|---|---|---|---|
| 1.25 | 0.1 | 0.451 (0.130) | 38.0 (7.6) |
| 1.25 | 0.25 | 1.13 (0.325) | 94.5 (18.7) |
| 2.00 | 0.1 | 0.723 (0.208) | 60.5 (12.1) |
| 2.00 | 0.25 | 1.82 (0.522) | 147 (29.3) |
