Table 3.
Predictive value of BAR for adverse endpoints.
| Unadjusted | Adjusted | |||
|---|---|---|---|---|
| OR/HR (95%Cl) | P | OR/HR (95%Cl) | P | |
| MIMIC III # | ||||
| BAR as continuous variablea | ||||
| In-hospital mortality | 1.12 (1.09–1.15) | <0.001 | 1.07 (1.02–1.12) | 0.003 |
| ICU mortality | 1.11 (1.08–1.14) | <0.001 | 1.07 (1.02–1.13) | 0.006 |
| 1-year mortality | 1.09 (1.08–1.10) | <0.001 | 1.06 (1.03–1.08) | <0.001 |
| ICU stay ≥ 5 days | 1.15 (1.13–1.18) | <0.001 | 1.08 (1.05–1.11) | <0.001 |
| Hospital stay ≥ 15 days | 1.14 (1.11–1.16) | <0.001 | 1.08 (1.05–1.11) | <0.001 |
| BAR as nominal variableb | ||||
| In-hospital mortality | 5.59 (3.35–9.31) | <0.001 | 2.70 (1.47–4.96) | 0.001 |
| ICU mortality | 4.97 (2.88–8.57) | <0.001 | 2.77 (1.44–5.32) | 0.002 |
| 1-year mortality | 5.61 (4.24–7.43) | <0.001 | 2.73 (1.97–3.79) | <0.001 |
| ICU stay ≥ 5 days | 3.60 (3.00–4.31) | <0.001 | 1.90 (1.50–2.41) | <0.001 |
| Hospital stay ≥ 15 days | 3.60 (2.98–4.35) | <0.001 | 2.06 (1.61–2.63) | <0.001 |
| eICU# | ||||
| BAR as continuous variablea | ||||
| In-hospital mortality | 1.10 (1.08–1.13) | <0.001 | 1.06 (1.01–1.10) | 0.013 |
| ICU mortality | 1.10 (1.08–1.13) | <0.001 | 1.06 (1.02–1.11) | 0.006 |
| ICU stay ≥ 5 days | 1.06 (1.04–1.07) | <0.001 | 1.03 (1.01–1.06) | 0.018 |
| Hospital stay ≥ 15 days | 1.13 (1.10–1.15) | <0.001 | 1.08 (1.05–1.11) | <0.001 |
| BAR as nominal variableb | ||||
| In-hospital mortality | 3.74 (2.52–5.55) | <0.001 | 2.21 (1.17–4.20) | 0.015 |
| ICU mortality | 4.81 (2.97–7.81) | <0.001 | 2.42 (1.19–4.92) | 0.015 |
| ICU stay ≥ 5 days | 1.87 (1.59–2.20) | <0.001 | 1.47 (1.14–1.89) | 0.003 |
| Hospital stay ≥ 15 days | 3.07 (2.57–3.67) | <0.001 | 2.04 (1.57–2.65) | <0.001 |
a
The OR was examined by per 1-point increase of BAR.
b
The OR was examined regarding the low BAR as reference.
#
The baseline model includes variables that are significant in univariate logistic proportional hazard analysis in MIMIC III, including age, SBP, heart rate, hypertension, heart failure, CKD, WBC, hemoglobin, SCr, sodium, glucose, anion gap, bicarbonate, ALT, AST, SOFA score and vasoactive (details shown in Supplementary Table 2).
OR, odds ratio; HR, hazard ratio; 95% CI, 95% confidence interval; MIMIC, Medical Information Mart for Intensive Care; BAR, blood urea nitrogen to serum albumin ratio; ICU, intensive care units.