Table 2.
Major findings of the included studies on alpha and beta diversity of gastric microbiota.
| No. | Study | Therapy | Follow-up | Changes of alpha diversity of gastric microbiota | Changes of beta diversity of gastric microbiota |
|---|---|---|---|---|---|
| 1 | (Yuan et al, 2021) | Quadruple therapy (amoxicillin 1000 mg + clarithromycin 500 mg + esomeprazole 20 mg + potassium bismuth citrate 200 mg, twice daily for 14 days) | 2 months | Shannon: ↑, Simpson: ↑ | Significant differences were reported after eradication |
| Probiotics supplemented quadruple therapy (amoxicillin 1000 mg + clarithromycin 500 mg + esomeprazole 20 mg + potassium bismuth citrate 200 mg, twice daily for 14 days) | 2 months | Shannon: ↑, Simpson: ↑ | Significant differences were reported after eradication | ||
| Probiotics monotherapy | 2 months | Shannon: NS, Simpson: NS | Significant differences were reported after eradication | ||
| 2 | (Watanabe et al, 2021) | Triple therapy (a PPI [esomeprazole, lansoprazole, or rabeprazole] or vonoprazan + amoxicillin + clarithromycin, twice daily for 7 days) | 13 months | Shannon: ↑, observed OTUs: NS, ACE: NS, Chao1: NS | Significant differences were reported after eradication |
| 3 | (Mao et al, 2021) | Quadruple therapy (omeprazole 20 mg + bismuth pectin 200 mg + furazolidone 100 mg + amoxicillin 1000 mg, twice daily for 14 days) | 4 weeks | observed species: ↑, Chao1: ↑, Shannon: ↑, Simpson: ↑ | Significant differences were reported after eradication |
| 4 | (Sung et al, 2020) | Triple therapy (omeprazole 20 mg + amoxicillin 1g + clarithromycin 500mg, twice daily for 7 days) | 1 year | Shannon: ↑ | Significant differences were reported after eradication |
| 5 | (Shin et al, 2020) | Triple therapy (a standard dose of PPI + amoxicillin 1g + clarithromycin 500 mg, twice daily for 7-14 days) | 57.4 months | Shannon: ↑, phylogenetic diversity: ↑ | Significant differences were reported after eradication |
| 6 | (Guo et al, 2020) | Quadruple therapy (omeprazole 20 mg [twice daily for 10 days] + tetracycline 750 mg [three times daily for 10 days] + metronidazole 400 mg [three times daily for 10 days] and bismuth citrate 300 mg [twice daily for 10 days]) | 6 months | Shannon: ↑, richness index: ↑ | Significant differences were reported after eradication |
| 7 | (Serrano et al, 2019) | Triple therapy (amoxicillin + clarithromycin + omeprazole, for 14 days) | 2 months | Shannon: ↑, Simpson: ↑ | Not reported |
| 8 | (He et al, 2019) | Quadruple therapy (esomeprazole 20 mg + bismuth subcitrate 220 mg + amoxicillin 1g + furazolidone 100 mg, twice daily for 14 days) | 6 weeks | Shannon: ↑, Sobs index: NS, Chao 1: NS | Significant differences were reported after eradication |
| 26 weeks | Shannon: ↑, Sobs index: ↑, Chao 1: ↑ | Significant differences were reported after eradication | |||
| 9 | (Li et al, 2017) | Triple therapy (esomeprazole 20 mg + amoxicillin 1g + clarithromycin 500 mg, twice daily for 7 days) | 8 weeks | Shannon: ↑, phylogenetic diversity: ↑ | Not reported |
NS, not significant; ↑, increased.