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. 2022 May 17;12:8243. doi: 10.1038/s41598-022-11996-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of GPCR orthologs shared between B. glabrata and S. mansoni miracidia. (A) Phylogenetic tree analysis of shared GPCRs, where each B. glabrata GPCR clusters with an ortholog receptor from S. mansoni. Bootstrap values support the confidence levels of clades. (B) Heatmap showing expression of shared GPCR- (in TPM) encoding genes in S. mansoni miracidia at 6 h post-hatch and different B. glabrata tissues. The columns represent S. mansoni miracidia biological replicates (1–3) and their mean, as well as Biomphalaria (glabrata) tissues.