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. 2022 May 4;13:853904. doi: 10.3389/fimmu.2022.853904

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Copyright © 2022 Li, Xu, Xu, Pan, Guo, Gu, Lin, Li, Li and Xiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TIME heterogeneity in pediatric pan-CNS tumors. (A) The proportions of immune cell-type infiltrations across lncRNA methylation clusters. (B) Heat maps showing the average immune cell infiltrations and immune signature scores across lncRNA methylation clusters. p-values were for ANOVA tests. (C) Violin plots showing the levels of immune cell infiltrations across lncRNA clusters. Left for CD4_Eff cells and right for fibroblast. (D) Heat maps showing the relative methylation of immune cell-type marker genes across patients in different lncRNA clusters. Genes were colored based on the immune cell types.