Table 2.
Baseline superficial and deep macular and radial peripapillary capillary vessel density, foveal avascular zone, and optic nerve head parameters of caffeine and placebo group
| Caffeine Group (n=60) | Placebo Group (n=60) | P | |
|---|---|---|---|
| Superficial Macular Vessel Density (VD) (%) | |||
| wiVD | 53.00 (52.05-53.97) | 52.75 (51.02-53.90) | 0.278† |
| Sup hemi VD | 52.90 (52.00-53.77) | 53.20 (52.02-54.60) | 0.271† |
| Inf hemi VD | 53.30 (52.20-54.20) | 53.20 (51.22-54.55) | 0.485† |
| Fovea | 22.14±6.78 | 23.24±7.05 | 0.386* |
| Parafovea | 55.95 (54.67-57.30) | 56.00 (54.65-58.02) | 0.522† |
| Para sup hemi | 55.85±2.64 | 56.22±3.13 | 0.915* |
| Para inf hemi | 56.15 (54.40-57.00) | 56.00 (54.47-58.02) | 0.596† |
| Para superior | 56.75 (55.02-58.50) | 56.80 (54.90-59.30) | 0.611† |
| Para nasal | 55.10 (53.70-56.57) | 55.40 (53.02-57.60) | 0.733† |
| Para inferior | 56.50 (55.50-58.00) | 56.80 (55.00-58.77) | 0.793† |
| Para temporal | 55.65 (53.62-57.27) | 56.05 (53.82-57.82) | 0.490† |
| Perifovea | 53.90 (52.70-54.67) | 53.72 (51.94-54.89) | 0.637† |
| Peri sup hemi | 53.80 (52.80-54.67) | 53.40 (51.70-55.15) | 0.416† |
| Peri inf hemi | 54.00 (52.90-54.90) | 54.05 (51.87-56.05) | 0.906† |
| Peri superior | 53.95 (52.30-55.25) | 53.70 (52.45-55.15) | 0.669† |
| Peri nasal | 57.65 (56.22-58.60) | 57.80 (55.62-59.77) | 0.620† |
| Peri inferior | 54.00 (52.60-55.62) | 54.50 (52.37-56.32) | 0.490† |
| Peri temporal | 50.40 (49.25-51.65) | 50.60 (48.82-52.70) | 0.285† |
| Deep Macular Vessel Density (VD)(%) | |||
| wiVD | 59.50 (56.15-61.47) | 59.30 (55.85-62.75) | 0.551† |
| Sup hemi VD | 58.90 (56.52-61.30) | 58.05 (53.42-60.65) | 0.078† |
| Inf hemi VD | 59.80 (56.30-61.55) | 59.90 (55.52-63.47) | 0.372† |
| Fovea | 40.90 (36.15-47.27) | 40.70 (35.62-47.15) | 0.867† |
| Parafovea | 60.95 (58.55-62.07) | 61.10 (57.82-62.97) | 0.700† |
| Para sup hemi | 61.10 (58.85-62.40) | 61.15 (57.50-63.05) | 0.773† |
| Para inf hemi | 61.30 (58.82-62.37) | 60.90 (57.70-63.40) | 0.914† |
| Para superior | 60.55 (58.42-62.10) | 60.25 (57.02-62.30) | 0.673† |
| Para nasal | 62.35 (60.42-63.57) | 62.10 (58.75-63.77) | 0.426† |
| Para inferior | 60.15 (58.02-61.60) | 58.45 (55.40-61.52) | 0.052† |
| Para temporal | 61.60 (59.82-62.75) | 61.90 (58.80-63.50) | 0.648† |
| Perifovea | 61.55 (57.95-63.10) | 61.10 (57.42-64.97) | 0.497† |
| Peri sup hemi | 60.95 (58.00-62.90) | 59.45 (54.55-62.47) | 0.051† |
| Peri inf hemi | 61.50 (58.35-63.70) | 61.85 (56.67-65.60) | 0.224† |
| Peri superior | 60.15 (57.92-63.27) | 59.00 (54.75-62.67) | 0.089† |
| Peri nasal | 60.55 (57.50-63.37) | 60.75 (54.62-64.27) | 0.948† |
| Peri inferior | 62.20 (58.77-64.65) | 62.65 (57.37-66.35) | 0.277† |
| Peri temporal | 62.40 (59.67-63.20) | 61.60 (58.25-64.85) | 0.956† |
| Radial peripapillary capillary vessel density (RPC VD) | |||
| wpVD | 50.48±2.06 | 50.70±2.06 | 0.564* |
| iVD | 53.32±3.74 | 53.97±4.09 | 0.367* |
| ppVD average | 53.00 (52.10-54.15) | 53.85 (52.25-55.45) | 0.138† |
| ppVD sup hemi | 53.33±2.13 | 53.22±2.59 | 0.797* |
| ppVD inf hemi | 53.26±2.40 | 53.44±2.87 | 0.718* |
| ppVD superior | 53.30±2.70 | 53.20±3.21 | 0.854* |
| ppVD nasal | 50.00 (48.25-52.00) | 51.00 (48.00-52.00) | 0.581† |
| ppVD inferior | 55.00 (53.25-57.00) | 54.00 (50.25-57.00) | 0.092† |
| ppVD temporal | 56.00 (53.00-57.75) | 55.00 (53.00-57.00) | 0.455† |
| Foveal avscular zone (FAZ) parameters | |||
| FAZ area (mm2) | 0.27±0.09 | 0.30±0.12 | 0.097* |
| FAZ perimeter (mm) | 2.06 (1.71-2.23) | 2.07 (1.86-2.36) | 0.265† |
| FD-300 | 57.05 (54.58-60.49) | 56.48 (54.10-59.77) | 0.229† |
wiVD: whole image vessel density, para: parafovea, peri: perifovea, sup hemi: superior hemifield, inf hemi: inferior hemifield, wpVD: whole papillary vessel density, İVD: inside disk vessel density, ppVD: peripapillary vessel density, FD: FAZ density. *Student t-test was used for comparison, †Mann-Whitney U test used for comparisons