Table 1.
Demographic and clinical features of subjects before surgery
| Trabeculectomy (n=45 eyes, 30 subjects) G1 | Trabeculectomy with MMC (n=36 eyes, 25 subjects) G2 | Combined surgery (n=34 eyes of 27 subjects) G3 | Test stat. | P | |
|---|---|---|---|---|---|
| Number of eyes | 45 | 36 | 34 | ||
| Median (IQR) age at presentation | 14 (8.3,17) | 16.3 (11.4,20.1) | 17.4 (12.3,21.8) | Kruskal-Wallis test | 0.03 |
| G1-G2 | Pairwise Wilcoxon rank-sum tests with Bonferroni correction | 0.20 | |||
| G1-G3 | 0.03 | ||||
| G2-G3 | 1 | ||||
| Median (IQR) age at surgery | 14.8 (8.4,17.6) | 17.4 (15,22.2) | 18.5 (13.7,22.6) | Kruskal-Wallis test | 0.007 |
| G1-G2 | Pairwise Wilcoxon rank-sum tests with Bonferroni correction | 0.03 | |||
| G1-G3 | 0.02 | ||||
| G2-G3 | 1 | ||||
| Gender, F:M | 3 (10%): 27 (90%) | 3 (12%): 22 (88%) | 2 (7%): 25 (93%) | Fisher’s exact test | 0.78 |
| Median (IQR) duration of VKC in months | 36 (24,48) | 34 (24,73.5) | 24 (12,48) | Kruskal-Wallis test | 0.18 |
| Preoperative steroid type | Fisher’s exact test | 0.06 | |||
| Low potent | 6 (13.3) | 1 (2.8) | 0 (0) | ||
| Mixed types | 26 (57.8) | 27 (75) | 28 (82.4) | ||
| Strong steroid | 13 (28.9) | 8 (22.2) | 6 (17.6) | ||
| Median (IQR) duration of steroid (in months) | 32 (12,48) | 25.5 (12,48) | 24 (12,47.5) | Kruskal-Wallis test | 0.52 |
| Median (IQR) LogMAR VA at first visit | 0.5 (0.4,1.3) | 0.7 (0.2,1.4) | 0.9 (0.4,1.3) | Kruskal-Wallis test | 0.59 |
| Median (IQR) LogMAR VA preoperative | 0.5 (0.3,1.2) | 0.4 (0,0.8) | 0.8 (0.5,1.3) | Kruskal-Wallis test | 0.02 |
| G1-G2 | Pairwise Wilcoxon rank-sum tests with Bonferroni correction | 0.60 | |||
| G1-G3 | 0.23 | ||||
| G2-G3 | 0.03 | ||||
| Mean (SD) IOP at first visit | 29.7 (13) | 32 (12.1) | 30.1 (12.9) | ANOVA F-test (2, 112 df) = 0.35 | 0.71 |
| Mean (SD) Preoperative IOP | 32 (8.9) | 29.4 (9.1) | 28.4 (12) | ANOVA F-test (2, 111 df) = 1.38 | 0.26 |
| Mean (SD) highest IOP | 37.6 (7.6) | 42.2 (8.1) | 37.6 (10.6) | ANOVA F-test (2, 112 df) = 3.39 | 0.04 |
| G1-G2 | Pairwise t tests with Bonferroni correction | 0.03 | |||
| G1-G3 | 1 | ||||
| G2-G3 | 0.20 | ||||
| Median (IQR) Number of preoperative AGM | 2 (2,3) | 3 (2,3) | 3 (2,3) | Kruskal-Wallis test | 0.21 |
| Preoperative median (IQR) CDR | 0.9 (0.8,0.9) | 0.9 (0.8,0.9) | 0.9 (0.8,1) | Kruskal-Wallis test | 0.27 |
| Type of VKC | Fisher’s exact test | 0.14 | |||
| Limbal + Tarsal | 39 (87) | 35 (97) | 33 (97) | ||
| Limbal | 5 (11) | 0 (0) | 1 (3) | ||
| Tarsal | 1 (2) | 1 (3) | 0 (0) | ||
| Cataract (PSC) | 25 (55.6) | 20 (55.6) | 34 (100) | ANOVA F-test | <0.001 |
| FU duration years | 4.18 (2,8) | 1.6 (.4,4) | 3.4 (.6,5.4) | Kruskal-Wallis test | 0.01* |
IQR: Interquartile range, SD: Standard deviation, MMC: Mitomycin C, IOP: Intraocular pressure, CDR: Cup-to-disc ratio, AGM: Anti-glaucoma medications, PSC: Posterior subcapsular cataract, FU: Follow-up, VKC: Vernal keratoconjunctivitis, F: Female, M: Male, LogMAR VA: Logarithm of the minimum angle of resolution. Follow-up duration was significantly less (P<0.01) in the trab MMC group compared to that in the trabeculectomy group