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. 2022 May 4;13:880769. doi: 10.3389/fimmu.2022.880769

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Copyright © 2022 Ning, Wu, Pan, Qiao, Li and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development and validation of CD4TLAs-Related Risk Signature. (A) Co-expression network of lncRNAs and CD4⁺ Tconv-related genes. (B) Cross‐validation for tuning parameter selection in the lasso regression. (C) Validation was performed for tuning parameter selection through the least absolute shrinkage and selection operator (LASSO) regression model for overall survival (OS). (D) The heatmap shows the expression distribution of A. (E) CD4TLAs-related prognostic model constructed in total BC patients. (F) Validation cohort 1. (G) Validation cohort 2. From top to bottom: Kaplan-Meier survival analysis of high- and low-RS subgroups; risk score between high- and low-risk groups; patient survival time; plots of the AUC for time-dependent ROC performance.