Figure 2.

The landscape of how diabetes is studied and cell sources available for researchers. [A (i-iii)]: Currently available models to study diabetes, such as human clinical trials, animal pre-clinical models, and in vitro cell culture systems. [A-(iv)] Relative breakdown of different characteristics of each available model for diabetes to highlight key advantages and disadvantages. (B) An outlook of available cell sources for diabetes modeling separated by 2D and 3D morphology. PBMCs, peripheral blood mononuclear cells; hiPSCs, human induced pluripotent stem cells; SC, Stem cell-derived; ECs, endothelial cells; βCs, β-like-cells; αCs, α-like-cells. Illustration not drawn to scale.