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. 2022 May 4;13:893692. doi: 10.3389/fmicb.2022.893692

FIGURE 3.

FIGURE 3

Assignment of protein in the proteome of sEVs to functional categories. (A) COG (Clusters of orthologous groups) functional categories of identified proteins in sEVs from T. vaginalis TV79-49c1+ and TV79-49c1–. Capital letters correspond to COG categories: A, RNA processing and modification; B, Chromatin structure and dynamics; C, Energy production and conversion; E, Amino acid transport and metabolism; F, Nucleotide transport and metabolism; G, Carbohydrate transport and metabolism; H, Coenzyme transport and metabolism; I, Lipid transport and metabolism; -J, Translation, ribosomal structure and biogenesis; K, Transcription; M, Cell wall, membrane, envelope biogenesis; O, Posttranslational modification, protein turnover, chaperones; P, Inorganic ion transport and metabolism; S, unknown function; T, Signal transduction mechanism; U, Intracellular trafficking, secretion, and vesicular transport; Z, Cytoskeleton. (B) Venn diagram comparing proteomes of sEVs, exosomes (Twu et al., 2013), surface proteome (De Miguel et al., 2010), and microvesicles (Nievas et al., 2018).