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. 2022 Feb 11;45(4):919–927. doi: 10.2337/dc21-2177

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© 2022 by the American Diabetes Association

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Rate of diabetic ketoacidosis with SGLT2 inhibitors (SGLT2is) compared with DPP-4 inhibitors (DPP-4is) and sulfonylureas among patients with type 2 diabetes. The x-axis displays HRs and 95% CIs on the logarithmic scale. The absolute increase in the incidence of diabetic ketoacidosis with SGLT2is per 1,000 person-years was 0.20 within 1 month, 0.95 within 6 months, and 1.73 within 1 year of treatment initiation for SGLT2is vs. DPP-4is, and 0.20 within 1 month, 0.96 within 6 months, and 1.72 within 1 year of treatment initiation for SGLT2is vs. sulfonylureas.