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Bisphosphonates in the development of ONJ. Geranylgeraniol could replenish the substrate for prenylation of GTPase, thereby reactivating the bone remodelling cycle and healing process to mitigate osteonecrosis of the jaw induced by bisphosphonates. Notes: Red arrows indicate the effects of bisphosphonates; blue arrows indicate the potential effects of geranylgeraniol supplementation.
