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. 2022 May 4;12:878920. doi: 10.3389/fonc.2022.878920

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Copyright © 2022 Vega, Nilsson, Kumar, Niitsu, Simmons, Ro, Wang, Chen, Joughin, Li, McKinley, Liu, Roland, Washington, Coffey, Lauffenburger and Lau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MxIF of cancer-associated fibroblasts to reveal their spatial distributions in APC and AOM/DSS tumors. (A) Representative stitched MxIF images of APC tumors and AOM/DSS tumors immunostained for CAF1 (SMA, VIM) and CAF2 (TNC, PDGFRα) subtypes. Tumor regions are visualized using immunostaining for β-catenin. (B) Representative binary images (here, AOM/DSS tumor sample) and (C) quantification of CAF1 and CAF2 marker expression within tumor regions of APC and AOM/DSS samples. n = 5 AOM/DSS tumors, n = 3 APC tumors *** indicates p < 0.001. (D) Visualization of CAF1 (SMA) and CAF2 (PDGFRα) subtype proximity to β-catenin+ tumor cells in APC and AOM/DSS samples, including tumor regions and adjacent normal regions.