TABLE 1.
List of proteins identified by Mass Spectrometry that associate with Septin 7 when phosphorylated at residue T426.
| Protein name | Gene | Function |
|---|---|---|
| 14-3-3 protein gamma | Ywhag | Binds phospho S/T proteins and moduIates their of activity |
| 14-3-3 protein zeta/delta | Ywhaz | Binds phospho S/T proteins and modulates their of activity |
| Myotrophin | Mtpn | Regulates growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex |
| Destrin | Dstn | Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin) |
| Fascin | Fscnl | Organization of actin filament bundles and the formation of microspikes and stress fibers |
| Profilin-2 | Pfn2 | Binds to actin and affects the structure of the cytoskeleton |
| Cofilin-1 | Cfll | Binds to F-actin and exhibits F-actin depolymerizing activity |
| Glutamine synthetase | Glul | Catalyzes the production ofglutamine and 4-am inobutanoate (gamma-aminobutyric acid, GABA) |
| Histidine triad nucleotide-binding protein 1 | Hintl | Hydrolyzes purine nucleotide phosphoramidates |
| Triosephosphate isomerase | Tpil | Triosephosphate isomerase 1 |
| Eukaryotic translation initiationfactor 5A-1; 5A-2 | Eif5a; Eif5a2 | mRNA-binding protein involved in translation elongation |
| Fatty acid-binding protein, brain | Fabp7 | Belongs to the calycin superfamily |
| Translationally-controlled tumor protein | Tptl | Involved in calcium binding and microtubule stabilization |
| Heterogenous nuclear ribonucleo protein A3 | Gm6793; Gm9242; Hnrnpa3 | Plays a role in cytoplasmic trafficking of RNA |
| SUMO-conjugating enzyme UBC9 | Ube2i | Necessary for sumoylation |
| Protein SET | Set | Multitasking protein, involved in apoptosis, transcription, and histone chaperoning |
| Guanine nucleotide-binding protein G(l)/G(S)/G(T) subunit beta-1; beta-2; beta-4 | Gnb1; Gnb2; Gnb4 | Guanine nucleotide-bind ing proteins act as a modulator in various transmembrane signaling events |
| NEDD8-conjugating enzyme Ubc12 | Ube2m | Ubiquitin conjugating enzyme |
| Ubiquitin-conjugating enzyme E2 D2; Ubiquitin-conjugating enzyme E2 D3; D2B | Ube2d2; Ube2d3; Ube2d2b | Ubiquitin conjugating enzyme |
| Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Ppp2r2a | Protein Phosphatase |
| Serine/arginine-rich splicing factor 2 | Srsf2 | Necessary for thesplicing of pre-mRNA |
| ADP/ATP translocase 1 | Slc25a4 | Involved in mitochondrial ADP/ATP transport |
| Peptidyl-prolyl cis-trans isomerase A; Peptidyl-prolyl cis-trans isomerase A | Ppia | PPlases accelerate the folding of proteins |
| 14 kDa phosphohistidine phosphatase | Phptl | Exhibits phosphohistidine phosphatase activity |
| Hepatoma-derived growth factor-related protein 2 | Hdgfrp2 | Associates with chromatin |
| Histone H4 | Histlh4a | Core component of nucleosome |
| Obg-like ATPase 1 | Olal | Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency |
| Small nuclear ribonucleoprotein Sm D3 | Snrpd3 | plays an important role in the splicing of cellular pre-mRNAs |
| l-lactate dehydrogenase A chain | Ldha | Lactatedehydrogenase A |
| Phosphoglycerate kinase 1 | Pgkl | Catalyzes one ofthe two ATP producing reactions in theglycolytic pathway |
| Aconitate hydratase, mitochondrial | Aco2 | Catalyzes the isomerization of citrateto isocitrate via cis-aconitate |
| Creatine kinase B-type | Ckb | Reversibly catalyzes thetransfer of phosphate between ATP and various phosphogens |
| Nucleolin | Ncl | Induces chromatin decondensation by binding to histone H1 |