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. 2022 May 17;10(5):e004475. doi: 10.1136/jitc-2021-004475

Figure 4.

Figure 4

HT high patients receiving antibacterial prophylaxis exhibit lower rates of bacterial infections. (A) Comparison of intravenous antibiotic use during the first 10 days after CAR-T transfusion in HT low (green) vs HT high (red) patients. Pip./Tazo=piperacillin/tazobactam, 3/4G = 3rd or fourth generation cephalosporin. Only antibiotics that were employed at least 10 times were included, for detailed list see online supplemental table 5; p values determined by Fisher’s exact test. (B, C) Cumulative incidence curves (day 0–90) for bacterial infections by antibacterial prophylaxis use (PPX) in HT low (B) and HT high (C) patients. Light shading indicates patients receiving antibacterial prophylaxis, while dark shading denotes no antibacterial prophylaxis use; p values were determined by Mantel-Cox log-rank test comparing PPX vs no PPX. CAR-T, chimeric antigen receptor T-cells; HT, CAR-HEMATOTOX.