Table 2.

Multivariable Cox proportional hazards model for severe (grade ≥3) infection

Cox proportional-hazards model for grade ≥3 infection (D0-90)	Adjusted HR (95% CI)	P value
Pre-CAR-T variables
Age (≥65 yo)	1.22 (0.73 to 2.03)	0.45
Disease entity (transformed lymphoma)	1.43 (0.77 to 2.66)	0.26
Prior ASCT	0.86 (0.47 to 1.59)	0.63
ECOG performance status (≥2)	1.10 (0.74 to 1.66)	0.64
LDH >ULN	0.95 (0.54 to 1.68)	0.86
Absolute lymphocyte count (ALC) <200 /µL	0.92 (0.49 to 1.71)	0.80
IgG Levels <4 g/L	0.85 (0.49 to 1.47)	0.55
CAR-HEMATOTOX (High)	6.14 (2.93 to 12.87)	<0.0001
Post-CART variables
CAR T-cell product (Tisa-cel)	1.31 (0.74 to 2.29)	0.35
ICU admission	1.22 (0.57 to 2.59)	0.61
CRS grade (ASTCT≥2°)	1.65 (0.87 to 3.16)	0.13
ICANS grade (ASTCT≥2°)	1.10 (0.50 to 2.38)	0.82
Tocilizumab use	0.93 (0.46 to 1.86)	0.83
Corticosteroid administration ≥9 days (≥10 mg Dexamethasone equivalent between D0-21)	2.08 (1.01 to 4.29)	0.047
G-CSF use	0.82 (0.44 to 1.54)	0.54
Antibacterial prophylaxis use	0.44 (0.26 to 0.77)	0.004
Severe neutropenia ≥14 days (ANC<500/µL between day 0 and 60)	3.13 (1.74 to 5.62)	<0.0001

Abbreviations: ANC, Absolute Neutrophil Count; G-CSF, Granulocyte-colony stimulating factor; ASTCT, American Society for Transplantation and Cellular Therapy; ECOG, Eastern Cooperative Oncology Group; ULN, Upper Limit of Normal; ICU, Intensive Care Unit.

CAR-T, chimeric antigen receptor T-cells; CRS, cytokine release syndrome; ICANS, immune effector cell-associated neurotoxicity syndrome; LDH, lactate dehydrogenase.